This review summarizes present evidence for the role of YKL-40 in the diagnosis, prognosis and cause of cardiovascular and alcoholic liver disease. The question of whether YKL-40 is merely a marker or a causal factor in the development of cardiovascular and liver disease is addressed, with emphasis …
YKL-40 immunoreactivity labeled astrocytes near a subset of amyloid plaques, implicating YKL-40 in the neuroinflammatory response to Aβ deposition. Conclusions: These data demonstrate that YKL-40, a putative indicator of neuroinflammation, is elevated in AD and, together with Aβ42, has potential prognostic utility as a biomarker for ...
· Chi3l1 knockout improves glial phagocytosis and suppresses amyloidosis. "We knocked out the core circadian clock to find dysregulated genes, and Chi3l1 came up," said Musiek. "We happened to run across this important AD biomarker in this circadian screening.". Chi3l1 encodes chitinase-3-like protein, aka YKL …
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YKL-40 expression is elevated in several neurodegenerative conditions and correlates with tau pathology. YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer''s disease and other tauopathies J Neuroinflammation. 2017 Jun 9;14(1):118. doi: 10.1186/s12974-017-0893-7. ...